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Sexual Function & Libido

Triptorelin

Trelstar; Decapeptyl

Classification: GnRH agonist (FDA-approved)

Mechanism: Superagonist of GnRH receptor; initial flare then downregulation for medical castration

Benefits: Prostate cancer; endometriosis; precocious puberty; HPG axis reset

Evidence tier: FDA-Approved · Availability: Prescription

Primary sources

  1. FDA Trelstar (triptorelin pamoate) prescribing information
  2. Lundström EA et al. Triptorelin 6-month formulation in locally advanced and metastatic prostate cancer — phase III study. Clin Drug Investig 2009. PMID 19888782
  3. Bolton EM et al. Are all gonadotrophin-releasing hormone agonists equivalent for prostate cancer? — systematic review. BJU Int 2018. PMID 29438592

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