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Sexual Function & Libido

Enclomiphene

Androxal; trans-clomiphene

Classification: SERM (non-peptide)

Mechanism: Estrogen receptor antagonist at hypothalamus; raises LH/FSH and endogenous testosterone

Benefits: Testosterone restoration; preserves fertility; raises LH/FSH

Evidence tier: Phase 3 (not approved standalone) · Availability: Research / Off-Label

Primary sources

  1. Wiehle RD et al. Enclomiphene citrate stimulates testosterone production while preventing oligospermia — phase II trial vs topical testosterone. Fertil Steril 2014. PMID 25044085
  2. Kaminetsky J et al. Oral enclomiphene citrate stimulates endogenous testosterone and sperm counts in men with low testosterone — comparison with testosterone gel. J Sex Med 2013. PMID 23530575

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