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Growth Hormone Secretion

Sermorelin

GRF 1-29; Geref

Classification: GHRH analog

Mechanism: Binds GHRH receptor on pituitary somatotrophs for pulsatile GH release

Benefits: Pulsatile GH/IGF-1 stimulation; sleep quality; anti-aging

Evidence tier: Formerly FDA-Approved (discontinued) · Availability: Compounding Restricted

Primary sources

  1. Barron JL et al. Growth hormone responses to growth hormone-releasing hormone (1-29)-NH2 and a D-Ala2 analog in normal men. Peptides 1985. PMID 2866496
  2. Achermann JC et al. The GH response to low-dose bolus GHRH(1-29)NH2 is attenuated in patients with longstanding post-irradiation GH insufficiency. Eur J Endocrinol 2000. PMID 10754477

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