PeptideHelper.org
Your evidence-based peptide reference
Research reference only. Not medical advice. Most compounds are not FDA-approved. Consult a qualified clinician before any human use.

Growth Hormone Secretion

MK-677

Ibutamoren; MK-0677; L-163191

Classification: Oral non-peptide ghrelin receptor agonist

Mechanism: GHS-R1a agonist; stimulates pulsatile GH/IGF-1 release; orally bioavailable spiropiperidine

Benefits: Increased GH/IGF-1; improved sleep; lean mass; bone density

Evidence tier: Phase 3 (not approved) · Availability: Research Chemical

Primary sources

  1. Nass R et al. Effects of an oral ghrelin mimetic (MK-677) on body composition and clinical outcomes in healthy older adults — randomized trial. Ann Intern Med 2008. PMID 18981485

Loading interactive view…