Cognitive Enhancement
PE-22-28
Spadin analog
Classification: Spadin-derived peptide; TREK-1 channel blocker
Mechanism: TREK-1 potassium channel inhibition; enhances serotonergic transmission; neurogenesis
Benefits: TREK-1 inhibition; antidepressant effect; neurogenesis
Evidence tier: Preclinical · Availability: Research
Primary sources
- Djillani A et al. Fighting against depression with TREK-1 blockers — past and future, focus on spadin. Pharmacol Ther 2019. PMID 30291907
- Note: Preclinical evidence only — no published human clinical trials. Cited paper describes in-vitro or animal-model mechanism.
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