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Cognitive Enhancement

Semax

ACTH(4-10) Pro-Gly-Pro analog

Classification: ACTH fragment analog; nootropic

Mechanism: Upregulates BDNF and NGF; modulates dopamine and serotonin systems; neuroprotective

Benefits: Enhanced focus and memory; BDNF elevation; neuroprotection; stroke recovery (Russia-approved)

Evidence tier: Russia-Approved + Anecdotal · Availability: Research / Intl Rx

Primary sources

  1. Gusev EI et al. The efficacy of semax in the treatment of patients at different stages of ischemic stroke. Zh Nevrol Psikhiatr Im S S Korsakova 2018. PMID 29798983
  2. Agapova TY et al. Neurotrophin gene expression in rat brain under the action of Semax, an analogue of ACTH 4-10. Neurosci Lett 2007. PMID 17353092

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