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Cognitive Enhancement

Dihexa

PNB-0408; N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

Classification: Angiotensin IV analog; HGF potentiator

Mechanism: Enhances HGF/c-Met signaling; promotes synaptogenesis and dendritic spine formation

Benefits: Potent HGF/c-Met signaling; synaptogenesis; memory/cognition (7 orders more potent than BDNF in some assays)

Evidence tier: Preclinical + Anecdotal · Availability: Research Chemical

Primary sources

  1. Benoist CC et al. The procognitive and synaptogenic effects of angiotensin IV-derived peptides depend on activation of the hepatocyte growth factor / c-Met system. J Pharmacol Exp Ther 2014. PMID 25187433
  2. Wright JW et al. The brain hepatocyte growth factor / c-Met receptor system — a new target for Alzheimer's disease treatment. J Alzheimers Dis 2015. PMID 25649658

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