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Skin, Hair & Cosmetic

Pal-GHK

Palmitoyl Tripeptide-1

Classification: Cosmetic lipopeptide (collagen)

Mechanism: Palmitoyl-modified GHK for enhanced penetration; copper-independent collagen signaling

Benefits: Collagen synthesis; anti-aging; skin repair

Evidence tier: Cosmetic Clinical Studies · Availability: Cosmetic

Primary sources

  1. Pickart L et al. The effect of the human peptide GHK on gene expression relevant to nervous system function and cognitive decline. Brain Sci 2017. PMID 28212278
  2. Maquart FX et al. In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu²⁺ in rat experimental wounds. J Clin Invest 1993. PMID 8227353
  3. Gorouhi F, Maibach HI. Role of topical peptides in preventing or treating aged skin. Int J Cosmet Sci 2009. PMID 19570099

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