Skin, Hair & Cosmetic
Argireline
Acetyl Hexapeptide-3; Acetyl Hexapeptide-8
Classification: Cosmetic peptide; SNAP-25 inhibitor
Mechanism: Mimics SNAP-25 N-terminus; inhibits neurotransmitter release at neuromuscular junction (topical)
Benefits: Topical wrinkle reduction (expression lines); Botox-like but milder
Evidence tier: Cosmetic Clinical Studies · Availability: Cosmetic
Primary sources
- Wang Y et al. The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects — randomized, placebo-controlled study. Am J Clin Dermatol 2013. PMID 23417317
- Zdrada-Nowak J et al. Acetyl hexapeptide-8 in cosmeceuticals — a review of skin permeability and efficacy. Int J Mol Sci 2025. PMID 40565185
- Aruan RR et al. Double-blind randomized trial on the effectiveness of acetylhexapeptide-3 cream and palmitoyl pentapeptide-4 cream for crow's feet. J Clin Aesthet Dermatol 2023. PMID 36909866
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