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Skin, Hair & Cosmetic

Matrixyl

Palmitoyl Pentapeptide-4; Matrixyl 3000

Classification: Cosmetic signal peptide; collagen stimulator

Mechanism: Mimics procollagen I fragment; signals fibroblasts to produce collagen, elastin, GAGs

Benefits: Collagen/ECM stimulation; wrinkle reduction; skin firmness

Evidence tier: Cosmetic Clinical Studies · Availability: Cosmetic

Primary sources

  1. Aruan RR et al. Double-blind randomized trial on the effectiveness of acetylhexapeptide-3 cream and palmitoyl pentapeptide-4 cream for crow's feet. J Clin Aesthet Dermatol 2023. PMID 36909866
  2. Gorouhi F, Maibach HI. Role of topical peptides in preventing or treating aged skin. Int J Cosmet Sci 2009. PMID 19570099
  3. Errante F et al. Cosmeceutical peptides in the framework of sustainable wellness economy. Front Chem 2020. PMID 33195061

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