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Skin, Hair & Cosmetic

Nonapeptide-1

Melanostatine-5

Classification: Cosmetic peptide; MC1R antagonist

Mechanism: Blocks α-MSH binding at MC1R; reduces melanogenesis

Benefits: Skin brightening; pigment control

Evidence tier: Cosmetic Clinical Studies · Availability: Cosmetic

Primary sources

  1. Errante F et al. Cosmeceutical peptides in the framework of sustainable wellness economy. Front Chem 2020. PMID 33195061
  2. Gorouhi F, Maibach HI. Role of topical peptides in preventing or treating aged skin. Int J Cosmet Sci 2009. PMID 19570099
  3. Note: Primary literature for this commercial cosmetic peptide is limited; cited reviews summarize available preclinical and clinical evidence.

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