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Tissue Repair & Healing

KPV

Lys-Pro-Val; α-MSH(11-13)

Classification: Tripeptide; α-MSH-derived anti-inflammatory

Mechanism: Inhibits NF-κB; stabilizes mast cells; reduces pro-inflammatory cytokines; mimics α-MSH C-terminus

Benefits: Potent anti-inflammatory; mast cell stabilization; gut barrier repair; IBD/colitis benefit; skin inflammation

Evidence tier: Preclinical + Anecdotal · Availability: Research

Primary sources

  1. Kannengiesser K et al. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis 2008. PMID 18092346

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