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Tissue Repair & Healing

ARA-290

Cibinetide; pHBSP

Classification: EPO-derived peptide; innate repair receptor (IRR) agonist

Mechanism: Activates IRR heterocomplex (EpoR/βcR); tissue protection without hematopoietic effect

Benefits: Small fiber neuropathy pain reduction; tissue protection; sarcoidosis neuropathy benefit

Evidence tier: Phase 2 · Availability: Investigational

Primary sources

  1. van Velzen M et al. ARA 290 for treatment of small fiber neuropathy in sarcoidosis. Expert Opin Investig Drugs 2014. PMID 24555851
  2. Culver DA et al. Cibinetide improves corneal nerve fiber abundance in patients with sarcoidosis-associated small nerve fiber loss and neuropathic pain. Invest Ophthalmol Vis Sci 2017. PMID 28475703

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