Anti-Aging & Longevity
NAD+
Nicotinamide Adenine Dinucleotide
Classification: Coenzyme (non-peptide); longevity supplement
Mechanism: Substrate for sirtuins and PARPs; essential for redox reactions and DNA repair
Benefits: Cellular energy; DNA repair; sirtuin activation; anti-aging pathways
Evidence tier: Observational + Anecdotal · Availability: Supplement / IV Clinic
Primary sources
- Yi L et al. Efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults — randomized, multicenter, double-blind, placebo-controlled, dose-dependent clinical trial. GeroScience 2023. PMID 36482258
- Note: NAD+ itself is not absorbed orally; cited NMN trial is the closest peer-reviewed evidence for NAD+ precursor supplementation in humans.
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