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Growth Hormone Secretion

IGF-1 DES

Des(1-3) IGF-1

Classification: IGF-1 analog (truncated); anabolic

Mechanism: Truncated IGF-1 with reduced IGFBP binding for higher local receptor activity

Benefits: Localized muscle hyperplasia; more potent than native IGF-1

Evidence tier: Anecdotal + Animal Studies · Availability: Research Chemical

Primary sources

  1. Bagley CJ et al. A key functional role for the insulin-like growth factor 1 N-terminal pentapeptide. Biochem J 1989. PMID 2730580
  2. Remacle-Bonnet M et al. des-(1-3)-IGF-I, an insulin-like growth factor analog used to mimic a potential IGF-II autocrine loop, promotes the differentiation of human colon-carcinoma cells. Int J Cancer 1992. PMID 1281142

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