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Anti-Aging & Longevity

Humanin

HN

Classification: Mitochondrial-derived peptide (MDP); cytoprotective

Mechanism: Binds BAX and IGFBP3; anti-apoptotic; metabolic regulation

Benefits: Neuroprotection; anti-apoptotic; insulin sensitization; Alzheimer's models

Evidence tier: Preclinical + Animal Studies · Availability: Research

Primary sources

  1. Hashimoto Y et al. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ. Proc Natl Acad Sci USA 2001. PMID 11371646
  2. Niikura T et al. Humanin — after the discovery. Mol Neurobiol 2004. PMID 15655255

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