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01 / Handling & Storage

Storage conditions & stability

Practitioner-facing reference compiled from peptide handling and pharmacology literature.

What degrades peptide stability

  • Temperature fluctuations. Higher temperatures accelerate peptide degradation.
  • Freeze/thaw cycles. Among the fastest causes of potency loss.
  • Humidity. Moisture causes degradation and crystal formation, even inside lyophilized vials.
  • Light exposure. Bright artificial light or sunlight degrades quality.
  • Mechanical shock. Dropping lyophilized vials can cause aggregation, particle formation, and cavitation.

Recommended storage containers

  • Opaque, tightly-sealed container (wrap in foil if none available).
  • Desiccant packets (silica gel) to absorb ambient moisture.
  • Tightly fasten lid; refrigerate or freeze per expected storage duration.

Reconstituted vial, refrigerator

Reported shelf life: Up to 60-90 days (30-45 for NAD+ and AOD-9604)

  • Light-proof, airtight containers are used.
  • The refrigerator door is avoided: unnecessary agitation.
  • For aliquoting into the freezer (dosing vial > 1-2 months), a pH 5-6 buffer is used instead of bacteriostatic water, and the material is frozen only once.

Lyophilized (un-reconstituted) vial, reported shelf life

Room temp
Stable 30-60 days in a cool, dark, dry cupboard.
Refrigerator
Up to 1 year.
Freezer
2-3 years. Never subject to multiple freeze/thaw cycles.

Special cases

  • Lipo-C: Do NOT refrigerate: solution will gel. Store 68-77°F, away from light.

Frequently asked questions

How long do reconstituted peptides last in the refrigerator?

Up to 60-90 days (30-45 for NAD+ and AOD-9604) Light-proof, airtight containers are used, and storage away from the refrigerator door minimises agitation.

How should lyophilized (un-reconstituted) peptides be stored?

Room temp: Stable 30-60 days in a cool, dark, dry cupboard.. Refrigerator: Up to 1 year.. Freezer: 2-3 years. Never subject to multiple freeze/thaw cycles..

What degrades peptide stability?

Temperature fluctuations, freeze/thaw cycles, humidity, light exposure, and mechanical shock. Of these, freeze/thaw cycles are reported as one of the fastest ways to lose efficacy.

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