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Anti-Aging & Longevity

SS-31

Elamipretide; Bendavia; MTP-131

Classification: Mitochondria-targeted tetrapeptide

Mechanism: Binds cardiolipin on inner mitochondrial membrane; preserves electron transport chain function

Benefits: Mitochondrial function; cardiolipin protection; primary mitochondrial myopathy (Phase 3 mixed)

Evidence tier: Phase 3 (not approved) · Availability: Investigational

Primary sources

  1. Birk AV et al. The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin. J Am Soc Nephrol 2013. PMID 23813215
  2. Karaa A et al. Efficacy and safety of elamipretide in primary mitochondrial myopathy — MMPOWER-3 randomized clinical trial. Neurology 2023. PMID 37268435

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