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Weight Loss & Metabolic

MOTS-C

Mitochondrial ORF of 12S rRNA-c; MOTSc

Classification: Mitochondrial-derived peptide (MDP); metabolic regulator

Mechanism: Activates AMPK; regulates methionine-folate cycle; insulin sensitization; exercise mimetic

Benefits: Insulin sensitization; AMPK activation; metabolic and mitochondrial support

Evidence tier: Early Clinical + Animal Studies · Availability: Research

Primary sources

  1. Lee C et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab 2015. PMID 25738459
  2. Zempo H et al. A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide MOTS-c. Aging (Albany NY) 2021. PMID 33468709

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