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Sexual Function & Libido

hCG

Human chorionic gonadotropin; Pregnyl; Novarel; Ovidrel (recombinant choriogonadotropin alfa)

Classification: Placental glycoprotein hormone (FDA-approved); LH-receptor agonist

Mechanism: LH-receptor agonist with minor FSH-like activity; in males stimulates testicular Leydig cells to produce endogenous testosterone; in females maintains corpus luteum progesterone production and triggers ovulation

Benefits: FDA-approved: female anovulatory infertility / ovulation induction; prepubertal cryptorchidism; selected hypogonadotropic hypogonadism. Off-label clinical use: intratesticular testosterone preservation during exogenous-T therapy; spermatogenesis restoration; HPG restart-stack protocols

Evidence tier: FDA-Approved · Availability: Prescription

Primary sources

  1. FDA Pregnyl (chorionic gonadotropin for injection, USP) prescribing information
  2. Coviello AD et al. Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression. J Clin Endocrinol Metab 2005. PMID 15713727
  3. Ludwig M et al. Use of recombinant human chorionic gonadotropin in ovulation induction. Fertil Steril 2003. PMID 12738494

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